Assay Detail
Binding
CHEMBL5320535
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Inhibition of SARS-CoV-2 MPro
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.35 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5195325 | — | — | 1 | 7.82 |
| CHEMBL5270743 | — | — | 1 | 7.76 |
| CHEMBL5191060 | — | — | 1 | 7.72 |
| CHEMBL5076204 | — | — | 1 | 7.47 |
| CHEMBL4796938 | — | — | 1 | 7.28 |
| CHEMBL5075209 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5195325 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL5270743 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL5191060 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5076204 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4796938 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5075209 | — | IC50 | = | 900.0 | nM | 6.05 |