Assay Detail
Functional
CHEMBL5320542
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Antiviral activity against HCoV-229E infected in human MRC5 cells assessed as reduction of viral growth
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus 229E |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.03 | 7.32 |
| IC50 | 2 | 6.85 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191060 | — | — | 1 | 7.32 |
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 7.05 |
| CHEMBL1230135 | — | — | 1 | 6.85 |
| CHEMBL213054 | — | — | 1 | 6.85 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191060 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4777223 | PF-00835231 | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1230135 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL213054 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 190.0 | nM | 6.72 |