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Assay Detail

CHEMBL5320586

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitumor activity against human MCF7 cells assessed as cell growth inhibition
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment.
Astrain-Redin N, Sanmartin C, Sharma AK, Plano D.
J Med Chem (2023) 66 : 3703 -3731
PubMed 36858050 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.29 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL109480 TANESPIMYCIN 3.0 1 8.30
CHEMBL278315 GELDANAMYCIN 2.0 1 7.96
CHEMBL5407233 1 5.82
CHEMBL3978941 1 5.14
CHEMBL3288601 1 4.94
CHEMBL295316 PLUMBAGIN 1.0 1 4.91
CHEMBL3889498 1 4.86
CHEMBL3288599 1 4.83
CHEMBL43612 JUGLONE 1 4.78
CHEMBL3288598 1 4.62
CHEMBL3908579 1 4.59
CHEMBL3917529 1 4.54
CHEMBL3655717 1 4.49
CHEMBL3288600 1 4.24
CHEMBL591429 PAC-1 1.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL109480 TANESPIMYCIN IC50 = 5.0 nM 8.30
CHEMBL278315 GELDANAMYCIN IC50 = 11.0 nM 7.96
CHEMBL5407233 IC50 = 1500.0 nM 5.82
CHEMBL3978941 IC50 = 7300.0 nM 5.14
CHEMBL3288601 IC50 = 11600.0 nM 4.94
CHEMBL295316 PLUMBAGIN IC50 = 12200.0 nM 4.91
CHEMBL3889498 IC50 = 13800.0 nM 4.86
CHEMBL3288599 IC50 = 14700.0 nM 4.83
CHEMBL43612 JUGLONE IC50 = 16500.0 nM 4.78
CHEMBL3288598 IC50 = 24000.0 nM 4.62
CHEMBL3908579 IC50 = 25700.0 nM 4.59
CHEMBL3917529 IC50 = 29000.0 nM 4.54
CHEMBL3655717 IC50 = 32700.0 nM 4.49
CHEMBL3288600 IC50 = 58200.0 nM 4.24
CHEMBL591429 PAC-1 IC50 > 75000.0 nM -