Assay Detail

CHEMBL5320597

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Functional

Antitumor activity against human SK-BR-3 cells assessed as cell growth inhibition

ChEMBL ↗

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Target

SK-BR-3 (CHEMBL613834) ↗

Open DB target context

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SK-BR-3 (CHEMBL613834) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SK-BR-3

CHEMBL613834

Anchored from Assay target.

Protein identity SK-BR-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SK-BR-3
Confidence	1 — Organism
Curated By	Autocuration

Target

SK-BR-3 (CHEMBL613834) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment.

Astrain-Redin N, Sanmartin C, Sharma AK, Plano D.
J Med Chem (2023) 66 : 3703 -3731
PubMed 36858050 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL109480	TANESPIMYCIN	3.0	1	8.40
CHEMBL278315	GELDANAMYCIN	2.0	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL109480	TANESPIMYCIN	IC50	=	4.0	nM	8.40
CHEMBL278315	GELDANAMYCIN	IC50	=	4.0	nM	8.40