Assay Detail
Functional
CHEMBL5323115
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Antiproliferative activity against BaF3 cells expressing human CSF1R assessed as suppression of cell proliferation incubated for 72 hrs by Cell Titer Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.18 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 7.22 |
| CHEMBL5415149 | — | — | 1 | 5.82 |
| CHEMBL5404686 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5415149 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5404686 | — | IC50 | = | 3100.0 | nM | 5.51 |