Assay Detail
Binding
CHEMBL5323116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to autoinhibited form of CSF1R (unknown origin) assessed as dissociation constant incubated for 1 hr by qPCR based Hill equation analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.97 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415149 | — | — | 1 | 9.30 |
| CHEMBL5404686 | — | — | 1 | 8.35 |
| CHEMBL5407395 | — | — | 1 | 7.77 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415149 | — | Kd | = | 0.5 | nM | 9.30 |
| CHEMBL5404686 | — | Kd | = | 4.5 | nM | 8.35 |
| CHEMBL5407395 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL3813873 | PEXIDARTINIB | Kd | = | 360.0 | nM | 6.44 |