Assay Detail
Binding
CHEMBL5323117
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Binding affinity to non-autoinhibited form of CSF1R (unknown origin) assessed as dissociation constant incubated for 1 hr by qPCR based Hill equation analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.36 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 8.24 |
| CHEMBL5415149 | — | — | 1 | 7.44 |
| CHEMBL5404686 | — | — | 1 | 7.10 |
| CHEMBL5407395 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3813873 | PEXIDARTINIB | Kd | = | 5.8 | nM | 8.24 |
| CHEMBL5415149 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL5404686 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL5407395 | — | Kd | = | 220.0 | nM | 6.66 |