Assay Detail
Functional
CHEMBL5323880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 8.66 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5409504 | — | — | 1 | 10.15 |
| CHEMBL5426241 | — | — | 1 | 9.85 |
| CHEMBL5403690 | — | — | 1 | 9.68 |
| CHEMBL5411251 | — | — | 1 | 9.68 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 9.62 |
| CHEMBL5428756 | — | — | 1 | 9.55 |
| CHEMBL5410841 | — | — | 1 | 9.55 |
| CHEMBL5439250 | — | — | 1 | 9.47 |
| CHEMBL5421825 | — | — | 1 | 9.46 |
| CHEMBL5431016 | — | — | 1 | 9.42 |
| CHEMBL5427417 | — | — | 1 | 9.36 |
| CHEMBL5433322 | — | — | 1 | 9.32 |
| CHEMBL5408927 | — | — | 1 | 9.30 |
| CHEMBL5395135 | — | — | 1 | 9.21 |
| CHEMBL5439334 | — | — | 1 | 9.21 |
| CHEMBL5415961 | — | — | 1 | 9.21 |
| CHEMBL5089164 | — | — | 1 | 9.12 |
| CHEMBL5427282 | — | — | 1 | 9.03 |
| CHEMBL5438311 | — | — | 1 | 9.00 |
| CHEMBL5424522 | — | — | 1 | 8.96 |
| CHEMBL5409206 | — | — | 1 | 8.92 |
| CHEMBL5433221 | — | — | 1 | 8.87 |
| CHEMBL5428033 | — | — | 1 | 8.84 |
| CHEMBL5433344 | — | — | 1 | 8.80 |
| CHEMBL5432487 | — | — | 1 | 8.75 |
| CHEMBL5413462 | — | — | 1 | 8.68 |
| CHEMBL5419654 | — | — | 1 | 8.66 |
| CHEMBL5430670 | — | — | 1 | 8.65 |
| CHEMBL5412757 | — | — | 1 | 8.62 |
| CHEMBL5394796 | — | — | 1 | 8.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5409504 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL5426241 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL5411251 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL5403690 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL5428756 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL5410841 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL5439250 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL5421825 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL5431016 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL5427417 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL5433322 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL5408927 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5439334 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL5395135 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL5415961 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL5089164 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL5427282 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL5438311 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL5424522 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5409206 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5433221 | — | IC50 | = | 1.36 | nM | 8.87 |
| CHEMBL5428033 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL5433344 | — | IC50 | = | 1.59 | nM | 8.80 |
| CHEMBL5432487 | — | IC50 | = | 1.77 | nM | 8.75 |
| CHEMBL5413462 | — | IC50 | = | 2.07 | nM | 8.68 |
| CHEMBL5419654 | — | IC50 | = | 2.21 | nM | 8.66 |
| CHEMBL5430670 | — | IC50 | = | 2.26 | nM | 8.65 |
| CHEMBL5412757 | — | IC50 | = | 2.38 | nM | 8.62 |
| CHEMBL5394796 | — | IC50 | = | 2.71 | nM | 8.57 |
| CHEMBL5425583 | — | IC50 | = | 5.89 | nM | 8.23 |
| CHEMBL5432385 | — | IC50 | = | 6.21 | nM | 8.21 |
| CHEMBL5401396 | — | IC50 | = | 6.79 | nM | 8.17 |
| CHEMBL5398690 | — | IC50 | = | 8.26 | nM | 8.08 |
| CHEMBL5407292 | — | IC50 | = | 9.51 | nM | 8.02 |
| CHEMBL5431718 | — | IC50 | = | 12.66 | nM | 7.90 |
| CHEMBL5410542 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL5420001 | — | IC50 | = | 20.68 | nM | 7.68 |
| CHEMBL5433681 | — | IC50 | = | 21.44 | nM | 7.67 |
| CHEMBL5409205 | — | IC50 | = | 22.39 | nM | 7.65 |
| CHEMBL5401693 | — | IC50 | = | 27.92 | nM | 7.55 |
| CHEMBL5420872 | — | IC50 | = | 36.02 | nM | 7.44 |
| CHEMBL5420169 | — | IC50 | = | 39.71 | nM | 7.40 |
| CHEMBL5438895 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL5439325 | — | IC50 | = | 66.15 | nM | 7.18 |
| CHEMBL4169078 | SRA-737 | IC50 | = | 244.6 | nM | 6.61 |
| CHEMBL5428637 | — | IC50 | - | — | - | |
| CHEMBL5398934 | — | IC50 | - | — | - | |
| CHEMBL5429443 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5440060 | — | IC50 | - | — | - |