Assay Detail
Toxicity
CHEMBL5323882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-KIT (unknown origin) using peptide substrate TK-S and ATP as substrate incubated for 1 hr by HTRF assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.60 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428756 | — | — | 1 | 6.15 |
| CHEMBL5431016 | — | — | 1 | 6.04 |
| CHEMBL5409504 | — | — | 1 | 5.96 |
| CHEMBL5411251 | — | — | 1 | 5.75 |
| CHEMBL5403690 | — | — | 1 | 5.73 |
| CHEMBL5426241 | — | — | 1 | 5.70 |
| CHEMBL5410841 | — | — | 1 | 5.69 |
| CHEMBL5439250 | — | — | 1 | 5.65 |
| CHEMBL5433322 | — | — | 1 | 5.61 |
| CHEMBL5408927 | — | — | 1 | 5.51 |
| CHEMBL5427417 | — | — | 1 | 5.42 |
| CHEMBL5421825 | — | — | 1 | 5.34 |
| CHEMBL5409206 | — | — | 1 | 5.32 |
| CHEMBL5413462 | — | — | 1 | 5.32 |
| CHEMBL5419654 | — | — | 1 | 5.30 |
| CHEMBL5427282 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428756 | — | IC50 | = | 704.5 | nM | 6.15 |
| CHEMBL5431016 | — | IC50 | = | 901.85 | nM | 6.04 |
| CHEMBL5409504 | — | IC50 | = | 1083.5 | nM | 5.96 |
| CHEMBL5411251 | — | IC50 | = | 1795.5 | nM | 5.75 |
| CHEMBL5403690 | — | IC50 | = | 1874.0 | nM | 5.73 |
| CHEMBL5426241 | — | IC50 | = | 1985.0 | nM | 5.70 |
| CHEMBL5410841 | — | IC50 | = | 2031.0 | nM | 5.69 |
| CHEMBL5439250 | — | IC50 | = | 2238.0 | nM | 5.65 |
| CHEMBL5433322 | — | IC50 | = | 2464.5 | nM | 5.61 |
| CHEMBL5408927 | — | IC50 | = | 3094.5 | nM | 5.51 |
| CHEMBL5427417 | — | IC50 | = | 3840.5 | nM | 5.42 |
| CHEMBL5421825 | — | IC50 | = | 4616.5 | nM | 5.34 |
| CHEMBL5409206 | — | IC50 | = | 4774.5 | nM | 5.32 |
| CHEMBL5413462 | — | IC50 | = | 4776.5 | nM | 5.32 |
| CHEMBL5419654 | — | IC50 | = | 5057.5 | nM | 5.30 |
| CHEMBL5427282 | — | IC50 | = | 8914.0 | nM | 5.05 |