Assay Detail
Binding
CHEMBL5324321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PD-1/PD-L1 (unknown origin) protein-protein interaction incubated for 105 mins by HTRF assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Novel 4-Arylindolines Containing a Pyrido[3,2-<i>d</i>]pyrimidine Moiety as the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction Inhibitors for Tumor Immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.64 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5421985 | — | — | 1 | 8.41 |
| CHEMBL5409456 | — | — | 1 | 8.20 |
| CHEMBL5394510 | — | — | 1 | 8.17 |
| CHEMBL5420691 | — | — | 1 | 8.14 |
| CHEMBL5432939 | — | — | 1 | 8.09 |
| CHEMBL5431228 | — | — | 1 | 8.09 |
| CHEMBL5437158 | — | — | 1 | 8.07 |
| CHEMBL5410649 | — | — | 1 | 7.88 |
| CHEMBL5411532 | — | — | 1 | 7.86 |
| CHEMBL5426047 | — | — | 1 | 7.85 |
| CHEMBL5417260 | — | — | 1 | 7.81 |
| CHEMBL5434370 | — | — | 1 | 7.80 |
| CHEMBL5406608 | — | — | 1 | 7.80 |
| CHEMBL5437262 | — | — | 1 | 7.76 |
| CHEMBL4877207 | — | — | 1 | 7.72 |
| CHEMBL5406571 | — | — | 1 | 7.68 |
| CHEMBL5429040 | — | — | 1 | 7.67 |
| CHEMBL5395792 | — | — | 1 | 7.67 |
| CHEMBL5403502 | — | — | 1 | 7.64 |
| CHEMBL5401186 | — | — | 1 | 7.63 |
| CHEMBL5429732 | — | — | 1 | 7.58 |
| CHEMBL5434970 | — | — | 1 | 7.50 |
| CHEMBL5425398 | — | — | 1 | 7.50 |
| CHEMBL5394492 | — | — | 1 | 7.36 |
| CHEMBL5421914 | — | — | 1 | 7.35 |
| CHEMBL5406195 | — | — | 1 | 7.21 |
| CHEMBL5416096 | — | — | 1 | 7.17 |
| CHEMBL5422897 | — | — | 1 | 7.09 |
| CHEMBL5426313 | — | — | 1 | 7.07 |
| CHEMBL5395175 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5421985 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5409456 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5394510 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL5420691 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL5432939 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL5431228 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL5437158 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL5410649 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL5411532 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL5426047 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL5417260 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL5434370 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL5406608 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5437262 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL4877207 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL5406571 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL5429040 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL5395792 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL5403502 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL5401186 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL5429732 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL5434970 | — | IC50 | = | 31.7 | nM | 7.50 |
| CHEMBL5425398 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL5394492 | — | IC50 | = | 43.4 | nM | 7.36 |
| CHEMBL5421914 | — | IC50 | = | 44.4 | nM | 7.35 |
| CHEMBL5406195 | — | IC50 | = | 62.1 | nM | 7.21 |
| CHEMBL5416096 | — | IC50 | = | 67.9 | nM | 7.17 |
| CHEMBL5422897 | — | IC50 | = | 80.5 | nM | 7.09 |
| CHEMBL5426313 | — | IC50 | = | 84.5 | nM | 7.07 |
| CHEMBL5395175 | — | IC50 | = | 108.2 | nM | 6.97 |
| CHEMBL5435514 | — | IC50 | = | 126.2 | nM | 6.90 |
| CHEMBL5421944 | — | IC50 | = | 128.1 | nM | 6.89 |