Assay Detail
Binding
CHEMBL5324497
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Binding affinity to sigma2 receptor (unknown origin) assessed as inhibition constant
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of WLB-89462, a New Drug-like and Highly Selective σ<sub>2</sub> Receptor Ligand with Neuroprotective Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.47 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61479 | SIRAMESINE | 2.0 | 1 | 9.92 |
| CHEMBL5426155 | — | — | 1 | 9.37 |
| CHEMBL53325 | — | — | 1 | 9.17 |
| CHEMBL4846092 | — | — | 1 | 8.10 |
| CHEMBL4297605 | ROLUPERIDONE | 3.0 | 1 | 8.09 |
| CHEMBL5189158 | — | — | 1 | 7.34 |
| CHEMBL5395401 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61479 | SIRAMESINE | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL5426155 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL53325 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL4846092 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4297605 | ROLUPERIDONE | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL5189158 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL5395401 | — | Ki | = | 47.0 | nM | 7.33 |