Assay Detail
Binding
CHEMBL5325035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR phosphorylation in human A-431 cells incubated for 4 hr by Western blot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.68 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | 4.0 | 1 | 8.00 |
| CHEMBL5438568 | — | — | 1 | 7.80 |
| CHEMBL5429059 | — | — | 1 | 5.60 |
| CHEMBL5440872 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5438568 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5429059 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL5440872 | — | IC50 | = | 5011.87 | nM | 5.30 |