Assay Detail
Binding
CHEMBL5325150
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to HDAC3 (unknown origin) assessed as inhibition constant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.29 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413269 | — | — | 1 | 10.40 |
| CHEMBL99392 | — | — | 1 | 9.70 |
| CHEMBL279636 | — | — | 1 | 9.52 |
| CHEMBL5423446 | — | — | 1 | 6.22 |
| CHEMBL5410602 | — | — | 1 | 5.60 |
| CHEMBL113537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413269 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL99392 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL279636 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL5423446 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL5410602 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL113537 | — | Ki | ~ | 11.0 | nM | - |