Assay Detail
Binding
CHEMBL5325516
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Binding affinity to NDM1 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-Vis spectrophotometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 4.87 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798128 | — | — | 1 | 5.38 |
| CHEMBL4757595 | — | — | 1 | 5.19 |
| CHEMBL5412062 | — | — | 1 | 5.17 |
| CHEMBL5410303 | — | — | 1 | 5.02 |
| CHEMBL5402541 | — | — | 1 | 4.92 |
| CHEMBL5432082 | — | — | 1 | 4.84 |
| CHEMBL5409951 | — | — | 1 | 4.82 |
| CHEMBL5414194 | — | — | 1 | 4.81 |
| CHEMBL5425633 | — | — | 1 | 4.76 |
| CHEMBL5413869 | — | — | 1 | 4.65 |
| CHEMBL5431286 | — | — | 1 | 4.55 |
| CHEMBL5414834 | — | — | 1 | 4.38 |
| CHEMBL4754134 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798128 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL4757595 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL5412062 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL5410303 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL5402541 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL5432082 | — | Ki | = | 14300.0 | nM | 4.84 |
| CHEMBL5409951 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL5414194 | — | Ki | = | 15400.0 | nM | 4.81 |
| CHEMBL5425633 | — | Ki | = | 17400.0 | nM | 4.76 |
| CHEMBL5413869 | — | Ki | = | 22400.0 | nM | 4.65 |
| CHEMBL5431286 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL5414834 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL4754134 | — | Ki | - | — | - |