Assay Detail
ADMET
CHEMBL5325812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP1A2 (unknown origin) incubated for 10 mins in presence of NADPH by resorufin dye based fluorescence analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Cytochrome P450 1B1 Inhibitors <i>via</i> a Scaffold-Hopping Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.34 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406710 | — | — | 1 | 7.17 |
| CHEMBL46909 | — | — | 1 | 5.51 |
| CHEMBL5412548 | — | — | 1 | - |
| CHEMBL5394220 | — | — | 1 | - |
| CHEMBL5406218 | — | — | 1 | - |
| CHEMBL5425709 | — | — | 1 | - |
| CHEMBL5401046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406710 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL46909 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5412548 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5394220 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5406218 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5425709 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5401046 | — | IC50 | > | 10000.0 | nM | - |