Assay Detail
Binding
CHEMBL5326163
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human recombinant tyrosinase expressed in Sf9 cells using L-DOPA as substrate by Michelis-Menten based analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting HOPNO-dicopper center interaction to development of inhibitors for human tyrosinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.89 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436239 | — | — | 1 | 5.22 |
| CHEMBL5434151 | — | — | 1 | 5.12 |
| CHEMBL5434506 | — | — | 1 | 5.10 |
| CHEMBL5432409 | — | — | 1 | 4.12 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL3898657 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436239 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL5434151 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL5434506 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL5432409 | — | Ki | = | 76000.0 | nM | 4.12 |
| CHEMBL287556 | KOJIC ACID | Ki | = | 350000.0 | nM | - |
| CHEMBL3898657 | — | Ki | = | 128000.0 | nM | - |