Assay Detail
Binding
CHEMBL5326166
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Competitive inhibition of Agaricus bisporus tyrosinase using L-DOPA as substrate by Michelis-Menten based analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Exploiting HOPNO-dicopper center interaction to development of inhibitors for human tyrosinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.48 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434151 | — | — | 1 | 5.92 |
| CHEMBL5436239 | — | — | 1 | 5.92 |
| CHEMBL3898657 | — | — | 1 | 5.75 |
| CHEMBL5434506 | — | — | 1 | 4.90 |
| CHEMBL5432409 | — | — | 1 | 4.89 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434151 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL5436239 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3898657 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL5434506 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL5432409 | — | Ki | = | 12800.0 | nM | 4.89 |
| CHEMBL287556 | KOJIC ACID | Ki | = | 102000.0 | nM | - |