Assay Detail
Binding
CHEMBL5326167
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Inhibition of tyrosinase in mouse B16-F10 cells assessed as inhibition of melanin production measured after 72 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting HOPNO-dicopper center interaction to development of inhibitors for human tyrosinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.64 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436239 | — | — | 1 | 5.00 |
| CHEMBL3898657 | — | — | 1 | 4.72 |
| CHEMBL5434151 | — | — | 1 | 4.21 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436239 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL3898657 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5434151 | — | IC50 | = | 61250.0 | nM | 4.21 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 108000.0 | nM | - |