Assay Detail
Binding
CHEMBL5326667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel protein 2 (CHEMBL4469) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of pyrrolopyrimidine derivatives as novel and selective positive modulator of the small conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.93 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499968 | — | — | 1 | 6.10 |
| CHEMBL5421015 | — | — | 1 | 5.75 |
| CHEMBL452887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499968 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5421015 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL452887 | — | EC50 | = | 722000.0 | nM | - |