Compound Detail
CHEMBL5421015
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Basic Information
| ChEMBL ID | CHEMBL5421015 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DVQOPNIPUIOXHU-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
353.8
MW (Da)
3.56
ALogP
7
HBA
1
HBD
73.5
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel protein 3 CHEMBL3381 | EC50 | 6.85 | 6.85 | 140.0 | 1 |
| Small conductance calcium-activated potassium channel protein 2 CHEMBL4469 | EC50 | 5.75 | 5.75 | 1800.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.74 | 5.74 | 1830.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel protein 3 | EC50 | = | 140.0 | nM | 6.85 | Positive modulation of SK3 in HEK293 cells in presence of Ca2+ by patch-clamp me... | 37068385 |
| Small conductance calcium-activated potassium channel protein 2 | EC50 | = | 1800.0 | nM | 5.75 | Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp me... | 37068385 |
| Unchecked | EC50 | = | 1830.0 | nM | 5.74 | Activation of rat SK2 variant a transfected in human tsA201 cells coexpressing C... | 37068385 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37068385 | 10.1016/j.ejmech.2023.115353 | Small conductance calcium-activated potassium channel protein 2 | 2 |
| 37068385 | 10.1016/j.ejmech.2023.115353 | Small conductance calcium-activated potassium channel protein 3 | 2 |
| 37068385 | 10.1016/j.ejmech.2023.115353 | Small conductance calcium-activated potassium channel protein 1 | 1 |
| 37068385 | 10.1016/j.ejmech.2023.115353 | Unchecked | 1 |
| 37068385 | 10.1016/j.ejmech.2023.115353 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine