Assay Detail
Binding
CHEMBL5326672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of rat SK2 variant a transfected in human tsA201 cells coexpressing CaM/GFP in presence of Ca2+ by Fluo-4 staining based electrophysiological method
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | tsA201 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of pyrrolopyrimidine derivatives as novel and selective positive modulator of the small conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 5.47 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403198 | — | — | 1 | 6.47 |
| CHEMBL5412913 | — | — | 1 | 6.32 |
| CHEMBL5412532 | — | — | 1 | 6.30 |
| CHEMBL5402800 | — | — | 1 | 6.14 |
| CHEMBL5426485 | — | — | 1 | 5.92 |
| CHEMBL5427458 | — | — | 1 | 5.80 |
| CHEMBL5438987 | — | — | 1 | 5.76 |
| CHEMBL5398226 | — | — | 1 | 5.75 |
| CHEMBL5421015 | — | — | 1 | 5.74 |
| CHEMBL5408455 | — | — | 1 | 5.71 |
| CHEMBL5408837 | — | — | 1 | 5.64 |
| CHEMBL5407203 | — | — | 1 | 5.53 |
| CHEMBL5423107 | — | — | 1 | 5.51 |
| CHEMBL5438679 | — | — | 1 | 5.47 |
| CHEMBL5405151 | — | — | 1 | 5.46 |
| CHEMBL5440403 | — | — | 1 | 5.44 |
| CHEMBL5423234 | — | — | 1 | 5.42 |
| CHEMBL5419617 | — | — | 1 | 5.39 |
| CHEMBL5414738 | — | — | 1 | 5.37 |
| CHEMBL5436837 | — | — | 1 | 5.24 |
| CHEMBL5436262 | — | — | 1 | 5.19 |
| CHEMBL5407939 | — | — | 1 | 5.18 |
| CHEMBL5439926 | — | — | 1 | 5.17 |
| CHEMBL5438952 | — | — | 1 | 5.11 |
| CHEMBL5407652 | — | — | 1 | 5.08 |
| CHEMBL5427852 | — | — | 1 | 5.07 |
| CHEMBL5433086 | — | — | 1 | 4.86 |
| CHEMBL5412396 | — | — | 1 | 4.72 |
| CHEMBL5397891 | — | — | 1 | 4.69 |
| CHEMBL5407100 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403198 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5412913 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5412532 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5402800 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5426485 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5427458 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5438987 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5398226 | — | EC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5421015 | — | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL5408455 | — | EC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL5408837 | — | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL5407203 | — | EC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5423107 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5438679 | — | EC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL5405151 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5440403 | — | EC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL5423234 | — | EC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL5419617 | — | EC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL5414738 | — | EC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL5436837 | — | EC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL5436262 | — | EC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL5407939 | — | EC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL5439926 | — | EC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL5438952 | — | EC50 | = | 7710.0 | nM | 5.11 |
| CHEMBL5407652 | — | EC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL5427852 | — | EC50 | = | 8430.0 | nM | 5.07 |
| CHEMBL5433086 | — | EC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL5412396 | — | EC50 | = | 19110.0 | nM | 4.72 |
| CHEMBL5397891 | — | EC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL5407100 | — | EC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL5407110 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5422240 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5402523 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5439372 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5423423 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5416413 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5439588 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5436322 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5409930 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5432185 | — | EC50 | > | 100000.0 | nM | - |