Assay Detail
Binding
CHEMBL5326702
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Inhibition of USP28 (149 to 703 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using Ub-AMC as substrate by fluorescence based analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase 28 (CHEMBL2157853) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based discovery of potent USP28 inhibitors derived from Vismodegib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.99 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5401467 | — | — | 1 | 7.40 |
| CHEMBL5431014 | — | — | 1 | 7.00 |
| CHEMBL5398929 | — | — | 1 | 6.96 |
| CHEMBL5402874 | — | — | 1 | 6.82 |
| CHEMBL5418668 | — | — | 1 | 6.52 |
| CHEMBL5400775 | — | — | 1 | 6.44 |
| CHEMBL5410351 | — | — | 1 | 5.95 |
| CHEMBL5399446 | — | — | 1 | 5.67 |
| CHEMBL5406507 | — | — | 1 | 5.55 |
| CHEMBL5419136 | — | — | 1 | 5.53 |
| CHEMBL5410474 | — | — | 1 | 5.37 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 5.32 |
| CHEMBL5426174 | — | — | 1 | 5.25 |
| CHEMBL5399208 | — | — | 1 | 5.07 |
| CHEMBL5439629 | — | — | 1 | 4.96 |
| CHEMBL5428159 | — | — | 1 | - |
| CHEMBL5409128 | — | — | 1 | - |
| CHEMBL5411940 | — | — | 1 | - |
| CHEMBL5395831 | — | — | 1 | - |
| CHEMBL5433505 | — | — | 1 | - |
| CHEMBL5430206 | — | — | 1 | - |
| CHEMBL5435891 | — | — | 1 | - |
| CHEMBL5398668 | — | — | 1 | - |
| CHEMBL5398084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5401467 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5431014 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5398929 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5402874 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5418668 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5400775 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5410351 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL5399446 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5406507 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL5419136 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL5410474 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL5426174 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL5399208 | — | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL5439629 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5428159 | — | IC50 | - | — | - | |
| CHEMBL5409128 | — | IC50 | - | — | - | |
| CHEMBL5411940 | — | IC50 | - | — | - | |
| CHEMBL5395831 | — | IC50 | - | — | - | |
| CHEMBL5433505 | — | IC50 | - | — | - | |
| CHEMBL5430206 | — | IC50 | - | — | - | |
| CHEMBL5435891 | — | IC50 | - | — | - | |
| CHEMBL5398668 | — | IC50 | - | — | - | |
| CHEMBL5398084 | — | IC50 | - | — | - |