Compound Detail
CHEMBL5426174
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Basic Information
| ChEMBL ID | CHEMBL5426174 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UKROYJHFBHSTHS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
435.3
MW (Da)
4.90
ALogP
4
HBA
2
HBD
89.3
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 28 CHEMBL2157853 | IC50 | 5.25 | 5.25 | 5680.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 28 | IC50 | = | 5680.0 | nM | 5.25 | Inhibition of USP28 (149 to 703 residues) (unknown origin) expressed in Escheric... | 37075624 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37075624 | 10.1016/j.ejmech.2023.115369 | Ubiquitin carboxyl-terminal hydrolase 28 | 2 |
Data from ChEMBL 36 via Core Engine