Assay Detail
Toxicity
CHEMBL5326795
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Inhibition of human Cathepsin L
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.51 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414071 | — | — | 1 | 7.70 |
| CHEMBL5426970 | — | — | 1 | 7.52 |
| CHEMBL5405589 | — | — | 1 | 7.52 |
| CHEMBL5433349 | — | — | 1 | 7.52 |
| CHEMBL5405557 | — | — | 1 | 7.52 |
| CHEMBL5396481 | — | — | 1 | 7.52 |
| CHEMBL5433524 | — | — | 1 | 7.40 |
| CHEMBL5402510 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414071 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5426970 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5405589 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5433349 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5405557 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5396481 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5433524 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5402510 | — | IC50 | = | 40.0 | nM | 7.40 |