Assay Detail
Binding
CHEMBL5327152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length human ZAK using MBP as substrate in presence off ATP by competitive binding assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 20 (CHEMBL3886) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 4.0 | nM | 8.40 |