Assay Detail
Functional
CHEMBL5327464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A-375 cells assessed as reduction in cell viability incubated for 48 hrs by CCk-8 assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione derivatives of brefeldin A: Design, synthesis and cytotoxicity in MDA-MB-231 human breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.06 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19980 | BREFELDIN A | — | 1 | 7.41 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.23 |
| CHEMBL5403345 | — | — | 1 | 6.28 |
| CHEMBL5438677 | — | — | 1 | 6.19 |
| CHEMBL5435512 | — | — | 1 | 6.08 |
| CHEMBL5420527 | — | — | 1 | 6.03 |
| CHEMBL5399866 | — | — | 1 | 5.97 |
| CHEMBL5423886 | — | — | 1 | 5.77 |
| CHEMBL5398095 | — | — | 1 | 5.74 |
| CHEMBL5428467 | — | — | 1 | 5.44 |
| CHEMBL5401692 | — | — | 1 | 4.52 |
| CHEMBL402341 | — | — | 1 | - |
| CHEMBL5405850 | — | — | 1 | - |
| CHEMBL5423485 | — | — | 1 | - |
| CHEMBL5395276 | — | — | 1 | - |
| CHEMBL5428463 | — | — | 1 | - |
| CHEMBL5397013 | — | — | 1 | - |
| CHEMBL5419421 | — | — | 1 | - |
| CHEMBL5407348 | — | — | 1 | - |
| CHEMBL5394303 | — | — | 1 | - |
| CHEMBL5414625 | — | — | 1 | - |
| CHEMBL5424303 | — | — | 1 | - |
| CHEMBL5412475 | — | — | 1 | - |
| CHEMBL5406439 | — | — | 1 | - |
| CHEMBL5416809 | — | — | 1 | - |
| CHEMBL5402975 | — | — | 1 | - |
| CHEMBL5402464 | — | — | 1 | - |
| CHEMBL5401771 | — | — | 1 | - |
| CHEMBL5436861 | — | — | 1 | - |
| CHEMBL5414388 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19980 | BREFELDIN A | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5403345 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5438677 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5435512 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5420527 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5399866 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5423886 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5398095 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL5428467 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL5401692 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL402341 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5405850 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5423485 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5395276 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5428463 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5397013 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5419421 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5407348 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5394303 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5414625 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5424303 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5412475 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5406439 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5416809 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5402975 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5402464 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5401771 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5436861 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5414388 | — | IC50 | > | 40000.0 | nM | - |