Assay Detail
Binding
CHEMBL5327666
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Inhibition of human GST-tagged MUS81-ECE1 expressed in Escherichia coli BL21(DE3)Rosetta2 cells incubated for 15 mins by FRET based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of small-molecule inhibitors of human MUS81-EME1/2 by FRET-based high-throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.91 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071130 | — | — | 1 | 6.25 |
| CHEMBL1200976 | IDARUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.21 |
| CHEMBL2354444 | PIRARUBICIN | 3.0 | 1 | 6.10 |
| CHEMBL5394285 | — | — | 1 | 6.00 |
| CHEMBL4084119 | LIRAGLUTIDE | 4.0 | 1 | 5.93 |
| CHEMBL5437637 | — | — | 1 | 5.90 |
| CHEMBL449392 | CORILAGIN | — | 1 | 5.89 |
| CHEMBL445177 | GINGKOLIC ACID | — | 1 | 5.84 |
| CHEMBL1241028 | — | — | 1 | 5.74 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | — | 1 | 5.70 |
| CHEMBL3289398 | — | — | 1 | 5.48 |
| CHEMBL1209885 | DYNASORE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071130 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1200976 | IDARUBICIN HYDROCHLORIDE | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2354444 | PIRARUBICIN | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5394285 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4084119 | LIRAGLUTIDE | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5437637 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL449392 | CORILAGIN | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL445177 | GINGKOLIC ACID | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL1241028 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL3289398 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL1209885 | DYNASORE | IC50 | ~ | 11500.0 | nM | - |