Assay Detail
Functional
CHEMBL5327795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Synergistic antiproliferative activity against human HCT-116 cells at JQ1 and compound 1:1 ratio incubated for 72 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and mechanism studies of dual EZH2/BRD4 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.90 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4532174 | — | — | 1 | 6.04 |
| CHEMBL5176169 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4532174 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5176169 | — | IC50 | = | 1760.0 | nM | 5.75 |