Assay Detail

CHEMBL5327988

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Binding

Inhibition of TYK2 dependent IFNalpha-stimulated STAT3 phosphorylation in human PBMC

ChEMBL ↗

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Target

Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗

Open DB target context

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Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Non-receptor tyrosine-protein kinase TYK2

CHEMBL3553

Anchored from Assay target.

Protein identity Non-receptor tyrosine-protein kinase TYK2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Cell Type	PBMC
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.

Leit S, Greenwood J, Carriero S, Mondal S, Abel R, Ashwell M, Blanchette H, Boyles NA, Cartwright M, Collis A, Feng S, Ghanakota P, Harriman GC, Hosagrahara V, Kaila N, Kapeller R, Rafi SB, Romero DL, Tarantino PM, Timaniya J, Toms AV, Wester RT, Westlin W, Srivastava B, Miao W, Tummino P, McElwee JJ, Edmondson SD, Masse CE.
J Med Chem (2023) 66 : 10473 -10496
PubMed 37427891 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.65	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5422616	—	—	1	8.77
CHEMBL4435170	DEUCRAVACITINIB	4.0	1	8.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5422616	—	IC50	=	1.7	nM	8.77
CHEMBL4435170	DEUCRAVACITINIB	IC50	=	3.0	nM	8.52