Assay Detail
Functional
CHEMBL5328048
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Antiproliferative activity against VEGFR2-transformed mouse BaF3 cells assessed as inhibition of cell proliferation incubated for 3 days by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and discovery of new selective and potent VEGF receptor 2 tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.74 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5411585 | — | — | 1 | 9.27 |
| CHEMBL491473 | CEDIRANIB | 3.0 | 1 | 8.77 |
| CHEMBL1289601 | LENVATINIB | 4.0 | 1 | 8.49 |
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | 8.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5411585 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL491473 | CEDIRANIB | IC50 | = | 1.71 | nM | 8.77 |
| CHEMBL1289601 | LENVATINIB | IC50 | = | 3.23 | nM | 8.49 |
| CHEMBL1946170 | REGORAFENIB | IC50 | = | 3.89 | nM | 8.41 |