Assay Detail
Binding
CHEMBL5328104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Gst-tagged human Pin1 assessed as inhibition constant by Western blot analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (CHEMBL2288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future Directions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.48 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5395865 | — | — | 1 | 8.92 |
| CHEMBL5400597 | — | — | 1 | 7.74 |
| CHEMBL5430490 | — | — | 1 | 7.70 |
| CHEMBL5396492 | — | — | 1 | 6.74 |
| CHEMBL5416154 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5395865 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL5400597 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL5430490 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL5396492 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL5416154 | — | Ki | = | 507.0 | nM | 6.29 |