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Assay Detail

CHEMBL5328241

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Pancreatic lipase (unknown origin) using 4-MUO as fluorescent substrate preincubated for 3 mins followed by substrate addition measured after 20 mins by microplate reader assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Pancreatic triacylglycerol lipase (CHEMBL1812)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase.
Zhao Y, Zhang M, Hou X, Han J, Qin X, Yang Y, Song Y, Liu Z, Zhang Y, Xu Z, Jia Q, Li Y, Chen K, Li B, Zhu W, Ge G.
Bioorg Med Chem (2023) 91 : 117413 -117413
PubMed 37490786 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.31 6.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL470029 OLEANONIC ACID 1 6.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL470029 OLEANONIC ACID IC50 = 490.0 nM 6.31