Assay Detail
Functional
CHEMBL5328256
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Induction of TIMP3 protein level in human HTB-94 cells incubated for 36 hrs by slot blotting analysis relative to 100 ug/ml suramin
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW1353 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.77 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 4.82 |
| CHEMBL5420211 | — | — | 1 | 4.77 |
| CHEMBL5421682 | — | — | 1 | 4.77 |
| CHEMBL5424371 | — | — | 1 | 4.72 |
| CHEMBL5425463 | — | — | 1 | - |
| CHEMBL5411796 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5420211 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5421682 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5424371 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5425463 | — | EC50 | - | — | - | |
| CHEMBL5411796 | — | EC50 | - | — | - |