Assay Detail
Binding
CHEMBL5328271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to SMARCA2 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Probable global transcription activator SNF2L2 (CHEMBL2362979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong <i>in vivo</i> Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.22 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5420238 | — | — | 1 | 8.00 |
| CHEMBL3752911 | — | — | 1 | 7.09 |
| CHEMBL3822689 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5420238 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL3752911 | — | Kd | = | 81.0 | nM | 7.09 |
| CHEMBL3822689 | — | Kd | = | 262.0 | nM | 6.58 |