Assay Detail
Binding
CHEMBL5328406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GLK (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 3 (CHEMBL5432) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of quinazoline HPK1 inhibitors with high cellular potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.81 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428695 | — | — | 1 | 9.10 |
| CHEMBL5396693 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428695 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5396693 | — | IC50 | = | 3.0 | nM | 8.52 |