Assay Detail
Binding
CHEMBL5328510
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Inhibition of GSK-3beta (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Glycogen synthase kinase-3: A potential target for diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.00 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1080901 | — | — | 1 | 10.22 |
| CHEMBL5410800 | — | — | 1 | 8.30 |
| CHEMBL412142 | LADUVIGLUSIB | 1.0 | 1 | 8.30 |
| CHEMBL1242830 | — | — | 1 | 8.10 |
| CHEMBL5434004 | — | — | 1 | 7.44 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 7.05 |
| CHEMBL523435 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1080901 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL5410800 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1242830 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5434004 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL445813 | AT-7519 | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL523435 | — | IC50 | = | 247.0 | nM | 6.61 |