Compound Detail
CHEMBL5434004
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Basic Information
| ChEMBL ID | CHEMBL5434004 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GUWCQTJKSPNEGT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
440.5
MW (Da)
2.34
ALogP
7
HBA
3
HBD
103.8
PSA (Ų)
0.46
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 7.44 | 7.44 | 36.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta | IC50 | = | 36.0 | nM | 7.44 | Inhibition of GSK-3beta (unknown origin) | 37536264 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37536264 | 10.1016/j.bmc.2023.117406 | Glycogen synthase kinase-3 beta | 1 |
Data from ChEMBL 36 via Core Engine