Assay Detail
Functional
CHEMBL5328892
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Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of chiral 1,4-diarylazetidin-2-one-based hydroxamic acid derivatives as novel tubulin polymerization inhibitors with histone deacetylase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.58 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410666 | — | — | 1 | 7.29 |
| CHEMBL5440334 | — | — | 1 | 7.22 |
| CHEMBL5431344 | — | — | 1 | 7.09 |
| CHEMBL4793994 | — | — | 1 | 6.63 |
| CHEMBL5437073 | — | — | 1 | 6.52 |
| CHEMBL5397397 | — | — | 1 | 6.40 |
| CHEMBL5431847 | — | — | 1 | 6.33 |
| CHEMBL5413310 | — | — | 1 | 6.30 |
| CHEMBL5408579 | — | — | 1 | 6.21 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.83 |
| CHEMBL5429899 | — | — | 1 | - |
| CHEMBL5423373 | — | — | 1 | - |
| CHEMBL5407261 | — | — | 1 | - |
| CHEMBL5397221 | — | — | 1 | - |
| CHEMBL5416032 | — | — | 1 | - |
| CHEMBL5419322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410666 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5440334 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5431344 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4793994 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL5437073 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL5397397 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL5431847 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL5413310 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5408579 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1489.0 | nM | 5.83 |
| CHEMBL5429899 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5423373 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5407261 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5397221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5416032 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5419322 | — | IC50 | > | 10000.0 | nM | - |