Assay Detail
Functional
CHEMBL5329538
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Cytotoxicity against human DLD1 cells assessed as reduction in cell proliferation incubated for 4 hrs under hypoxic condition followed by incubation for 5 days under oxic condition by sulforhodamine B staining based analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hypoxia-activated prodrugs of phenolic olaparib analogues for tumour-selective chemosensitisation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.48 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 1 | 6.07 |
| CHEMBL5403789 | — | — | 1 | 5.80 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 4.57 |
| CHEMBL5411944 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5403789 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL5411944 | — | IC50 | = | 100500.0 | nM | - |