Assay Detail
Functional
CHEMBL5329539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human DLD1 cells expressing BRCA2 knockout assessed as reduction in cell proliferation incubated for 4 hrs under oxic condition followed by incubation for 5 days under oxic condition by sulforhodamine B staining based analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hypoxia-activated prodrugs of phenolic olaparib analogues for tumour-selective chemosensitisation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.98 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 1 | 8.40 |
| CHEMBL5403789 | — | — | 1 | 7.85 |
| CHEMBL5411944 | — | — | 1 | 5.95 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5403789 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5411944 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 1910.0 | nM | 5.72 |