Assay Detail
Functional
CHEMBL5329964
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Antiinflammatory activity against LPS-stimulated dog DH82 cells assessed as reduction in NO production
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Cell Type | DH82 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitory effect of γ-ray-modified hydroxymethylated baicalins on NO production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.51 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405406 | — | — | 1 | 4.72 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 4.68 |
| CHEMBL5425726 | — | — | 1 | 4.60 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 4.51 |
| CHEMBL183513 | OROXYLIN A | — | 1 | 4.30 |
| CHEMBL5428729 | — | — | 1 | 4.24 |
| CHEMBL485818 | BAICALIN | — | 1 | - |
| CHEMBL5440982 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405406 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5425726 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL183513 | OROXYLIN A | IC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL5428729 | — | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL485818 | BAICALIN | IC50 | > | 200000.0 | nM | - |
| CHEMBL5440982 | — | IC50 | > | 200000.0 | nM | - |