Assay Detail
Functional
CHEMBL5330115
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Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of tricyclic heterocycles as core structures for RIOK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.55 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399070 | — | — | 1 | 5.98 |
| CHEMBL5172767 | — | — | 1 | 5.77 |
| CHEMBL5417058 | — | — | 1 | 5.62 |
| CHEMBL5411549 | — | — | 1 | 5.52 |
| CHEMBL5406944 | — | — | 1 | 5.48 |
| CHEMBL5416400 | — | — | 1 | 5.40 |
| CHEMBL5439857 | — | — | 1 | 5.33 |
| CHEMBL5417476 | — | — | 1 | 5.29 |
| CHEMBL5424801 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399070 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5172767 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5417058 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL5411549 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL5406944 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL5416400 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL5439857 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL5417476 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL5424801 | — | IC50 | > | 10000.0 | nM | - |