Assay Detail
Functional
CHEMBL5330149
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Antileishmanial activity against Leishmania infantum promastigotes
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of the 2-arylquinazoline-4(3<i>H</i>)one scaffold for a selective and potent antitrypanosomal agent: modulation of the mechanism of action through chemical functionalization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.34 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397544 | — | — | 1 | 6.11 |
| CHEMBL5434485 | — | — | 1 | 6.06 |
| CHEMBL5416931 | — | — | 1 | 5.92 |
| CHEMBL5431637 | — | — | 1 | 5.81 |
| CHEMBL5436408 | — | — | 1 | 5.67 |
| CHEMBL5408126 | — | — | 1 | 5.34 |
| CHEMBL5439802 | — | — | 1 | 5.34 |
| CHEMBL1163173 | — | — | 1 | 5.31 |
| CHEMBL5428702 | — | — | 1 | 5.30 |
| CHEMBL3289109 | — | — | 1 | 5.28 |
| CHEMBL2058057 | — | — | 1 | 5.16 |
| CHEMBL18688 | — | — | 1 | 5.06 |
| CHEMBL5407773 | — | — | 1 | 5.04 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.00 |
| CHEMBL5427953 | — | — | 1 | 4.90 |
| CHEMBL127066 | — | — | 1 | 4.88 |
| CHEMBL5402893 | — | — | 1 | 4.67 |
| CHEMBL4060330 | — | — | 1 | - |
| CHEMBL2058056 | — | — | 1 | - |
| CHEMBL5418693 | — | — | 1 | - |
| CHEMBL5422583 | — | — | 1 | - |
| CHEMBL5406203 | — | — | 1 | - |
| CHEMBL5431468 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397544 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5434485 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5416931 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5431637 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL5436408 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5408126 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL5439802 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL1163173 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL5428702 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL3289109 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL2058057 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL18688 | — | IC50 | = | 8670.0 | nM | 5.06 |
| CHEMBL5407773 | — | IC50 | = | 9070.0 | nM | 5.04 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5427953 | — | IC50 | = | 12670.0 | nM | 4.90 |
| CHEMBL127066 | — | IC50 | = | 13320.0 | nM | 4.88 |
| CHEMBL5402893 | — | IC50 | = | 21140.0 | nM | 4.67 |
| CHEMBL4060330 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2058056 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5418693 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5422583 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5406203 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5431468 | — | IC50 | > | 25000.0 | nM | - |