Assay Detail
Functional
CHEMBL5330550
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Anticancer activity against human NCI-H1975 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of EGFR kinase inhibitors that spans the orthosteric and allosteric sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.21 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422597 | — | — | 1 | 5.77 |
| CHEMBL5394899 | — | — | 1 | 5.73 |
| CHEMBL5394643 | — | — | 1 | 5.43 |
| CHEMBL5427645 | — | — | 1 | 5.29 |
| CHEMBL5427654 | — | — | 1 | 5.20 |
| CHEMBL5400243 | — | — | 1 | 5.06 |
| CHEMBL4565609 | — | — | 1 | 5.05 |
| CHEMBL5440904 | — | — | 1 | 5.03 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.00 |
| CHEMBL5424516 | — | — | 1 | 4.96 |
| CHEMBL5397284 | — | — | 1 | 4.84 |
| CHEMBL5440459 | — | — | 1 | - |
| CHEMBL5397063 | — | — | 1 | - |
| CHEMBL5422464 | — | — | 1 | - |
| CHEMBL5416664 | — | — | 1 | - |
| CHEMBL4284413 | — | — | 1 | - |
| CHEMBL5409028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422597 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5394899 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5394643 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL5427645 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL5427654 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL5400243 | — | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL4565609 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5440904 | — | IC50 | = | 9320.0 | nM | 5.03 |
| CHEMBL939 | GEFITINIB | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5424516 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5397284 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL5440459 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5397063 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5422464 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5416664 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4284413 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5409028 | — | IC50 | > | 20000.0 | nM | - |