Assay Detail
Binding
CHEMBL5330798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha-Synuclein (unknown origin) aggregation incubated for 72 hrs by ThT-based fluorescence analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Arylidene curcumin derivatives in vitro inhibit α-Synuclein aggregation and disaggregate the preformed fibril.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.76 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5435474 | — | — | 1 | 6.21 |
| CHEMBL5429959 | — | — | 1 | 5.97 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.48 |
| CHEMBL260079 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5435474 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5429959 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL140 | CURCUMIN | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL260079 | — | IC50 | = | 4390.0 | nM | 5.36 |