Assay Detail
Binding
CHEMBL5330824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SYK (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Review and prospects of targeted therapies for Spleen tyrosine kinase (SYK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.16 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3986824 | LANRAPLENIB | 2.0 | 1 | 8.21 |
| CHEMBL3265032 | ENTOSPLETINIB | 3.0 | 1 | 8.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3986824 | LANRAPLENIB | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3265032 | ENTOSPLETINIB | IC50 | = | 7.7 | nM | 8.11 |