Assay Detail
Functional
CHEMBL5331003
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Cytotoxicity against human Huh-7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.26 | 7.40 |
| GI | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399372 | — | — | 1 | 7.40 |
| CHEMBL5395601 | — | — | 1 | 7.00 |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 6.22 |
| CHEMBL5417466 | — | — | 1 | 6.16 |
| CHEMBL5414116 | — | — | 1 | 6.00 |
| CHEMBL5419328 | — | — | 1 | 5.89 |
| CHEMBL5425754 | — | — | 1 | 5.85 |
| CHEMBL5396168 | — | — | 1 | 5.82 |
| CHEMBL5401822 | — | — | 1 | 5.20 |
| CHEMBL5412907 | — | — | 1 | 5.17 |
| CHEMBL5405427 | — | — | 1 | 5.15 |
| CHEMBL5399841 | — | — | 1 | 5.10 |
| CHEMBL5413601 | — | — | 1 | 5.05 |
| CHEMBL5423587 | — | — | 1 | 4.97 |
| CHEMBL5419604 | — | — | 1 | 4.91 |
| CHEMBL5432334 | — | — | 1 | 4.89 |
| CHEMBL5417440 | — | — | 1 | 4.88 |
| CHEMBL5396771 | — | — | 1 | 4.83 |
| CHEMBL5425197 | — | — | 1 | 4.82 |
| CHEMBL5440123 | — | — | 1 | 4.81 |
| CHEMBL5432723 | — | — | 1 | 4.80 |
| CHEMBL5418133 | — | — | 1 | 4.62 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 4.61 |
| CHEMBL5399139 | — | — | 1 | 4.53 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.51 |
| CHEMBL5412035 | — | — | 1 | 4.46 |
| CHEMBL5403733 | — | — | 1 | 4.31 |
| CHEMBL1580 | PENTOSTATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399372 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5395601 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1619 | CLADRIBINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5417466 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5414116 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5419328 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5425754 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5396168 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5401822 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5412907 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5405427 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5399841 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5413601 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5423587 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL5419604 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL5432334 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL5417440 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL5396771 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL5425197 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL5440123 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL5432723 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5418133 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL5399139 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL5412035 | — | IC50 | = | 34400.0 | nM | 4.46 |
| CHEMBL5403733 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL1580 | PENTOSTATIN | GI | - | — | - |