Assay Detail
Functional
CHEMBL5331004
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Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
28
Total Activities
28
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.23 | 7.40 |
| GI | 2 | - | - |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399372 | — | — | 1 | 7.40 |
| CHEMBL5395601 | — | — | 1 | 6.22 |
| CHEMBL5417466 | — | — | 1 | 6.10 |
| CHEMBL5396168 | — | — | 1 | 5.80 |
| CHEMBL5425754 | — | — | 1 | 5.72 |
| CHEMBL5414116 | — | — | 1 | 5.68 |
| CHEMBL5419328 | — | — | 1 | 5.30 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.22 |
| CHEMBL5399139 | — | — | 1 | 5.22 |
| CHEMBL5412907 | — | — | 1 | 5.21 |
| CHEMBL5401822 | — | — | 1 | 5.18 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 5.08 |
| CHEMBL5399841 | — | — | 1 | 5.08 |
| CHEMBL5405427 | — | — | 1 | 4.98 |
| CHEMBL5396771 | — | — | 1 | 4.94 |
| CHEMBL5413601 | — | — | 1 | 4.92 |
| CHEMBL5417440 | — | — | 1 | 4.92 |
| CHEMBL5432334 | — | — | 1 | 4.86 |
| CHEMBL5418133 | — | — | 1 | 4.65 |
| CHEMBL5425197 | — | — | 1 | 4.58 |
| CHEMBL5419604 | — | — | 1 | 4.49 |
| CHEMBL5423587 | — | — | 1 | 4.41 |
| CHEMBL5412035 | — | — | 1 | 4.35 |
| CHEMBL1580 | PENTOSTATIN | 4.0 | 1 | - |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | - |
| CHEMBL5440123 | — | — | 1 | - |
| CHEMBL5432723 | — | — | 1 | - |
| CHEMBL5403733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399372 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5395601 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5417466 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5396168 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5425754 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5414116 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5419328 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5399139 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5412907 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5401822 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5399841 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5405427 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL5396771 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL5413601 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5417440 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5432334 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL5418133 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL5425197 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL5419604 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL5423587 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL5412035 | — | IC50 | = | 44800.0 | nM | 4.35 |
| CHEMBL1580 | PENTOSTATIN | GI | - | — | - | |
| CHEMBL1619 | CLADRIBINE | IC50 | < | 100.0 | nM | - |
| CHEMBL5440123 | — | GI | - | — | - | |
| CHEMBL5432723 | — | Inhibition | - | % | - | |
| CHEMBL5403733 | — | IC50 | = | 196600.0 | nM | - |