Assay Detail
Functional
CHEMBL5331007
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Cytotoxicity against human Hep3B cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.81 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399372 | — | — | 1 | 7.52 |
| CHEMBL5417466 | — | — | 1 | 7.00 |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 7.00 |
| CHEMBL5419328 | — | — | 1 | 6.52 |
| CHEMBL5395601 | — | — | 1 | 6.40 |
| CHEMBL5425754 | — | — | 1 | 5.51 |
| CHEMBL5399841 | — | — | 1 | 5.37 |
| CHEMBL5396168 | — | — | 1 | 5.37 |
| CHEMBL5413601 | — | — | 1 | 5.21 |
| CHEMBL5401822 | — | — | 1 | 5.17 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 4.56 |
| CHEMBL5405427 | — | — | 1 | 4.14 |
| CHEMBL5414116 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399372 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5417466 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1619 | CLADRIBINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5419328 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5395601 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5425754 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5399841 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5396168 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5413601 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5401822 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL5405427 | — | IC50 | = | 71800.0 | nM | 4.14 |
| CHEMBL5414116 | — | IC50 | < | 100.0 | nM | - |