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Assay Detail

CHEMBL5331150

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mushroom tyrosinase incubated for 10 mins by spectrophotometric analysis
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Agaricus bisporus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Mushroom tyrosinase (CHEMBL6066154)
Type PROTEIN FAMILY
Organism Agaricus bisporus

Publication

Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders.
Ghani U.
Eur J Med Chem (2022) 239 : 114525 -114525
PubMed 35717871 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 7.02 8.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5434603 1 8.79
CHEMBL5430416 1 8.78
CHEMBL5426437 1 8.78
CHEMBL5408010 1 8.71
CHEMBL5414043 1 7.85
CHEMBL5427541 1 7.72
CHEMBL5410853 1 7.72
CHEMBL5403008 1 6.77
CHEMBL5404236 1 6.72
CHEMBL5400872 1 5.83
CHEMBL5439533 1 5.33
CHEMBL5410448 1 5.27
CHEMBL5422809 1 5.25
CHEMBL5413193 1 4.82
CHEMBL5402849 1 -
CHEMBL5395899 1 -
CHEMBL5437301 1 -
CHEMBL5402434 1 -
CHEMBL5413069 1 -
CHEMBL5397262 1 -
CHEMBL5401857 1 -
CHEMBL5407270 1 -
CHEMBL5414630 1 -
CHEMBL5440075 1 -
CHEMBL5409723 1 -
CHEMBL5431318 1 -
CHEMBL5401386 1 -
CHEMBL5433797 1 -
CHEMBL5400338 1 -
CHEMBL5400453 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5434603 IC50 = 1.62 nM 8.79
CHEMBL5430416 IC50 = 1.66 nM 8.78
CHEMBL5426437 IC50 = 1.65 nM 8.78
CHEMBL5408010 IC50 = 1.97 nM 8.71
CHEMBL5414043 IC50 = 14.0 nM 7.85
CHEMBL5427541 IC50 = 19.0 nM 7.72
CHEMBL5410853 IC50 = 19.0 nM 7.72
CHEMBL5403008 IC50 = 170.0 nM 6.77
CHEMBL5404236 IC50 = 190.0 nM 6.72
CHEMBL5400872 IC50 = 1490.0 nM 5.83
CHEMBL5439533 IC50 = 4680.0 nM 5.33
CHEMBL5410448 IC50 = 5400.0 nM 5.27
CHEMBL5422809 IC50 = 5620.0 nM 5.25
CHEMBL5413193 IC50 = 15200.0 nM 4.82
CHEMBL5439368 IC50 > 20000.0 nM -
CHEMBL5436183 IC50 > 20000.0 nM -
CHEMBL5402849 IC50 > 20000.0 nM -
CHEMBL5395899 IC50 > 20000.0 nM -
CHEMBL5437301 IC50 > 20000.0 nM -
CHEMBL5402434 IC50 > 20000.0 nM -
CHEMBL5413069 IC50 > 20000.0 nM -
CHEMBL5397262 IC50 > 20000.0 nM -
CHEMBL5401857 IC50 > 20000.0 nM -
CHEMBL5407270 IC50 > 20000.0 nM -
CHEMBL5414630 IC50 > 20000.0 nM -
CHEMBL5440075 IC50 > 20000.0 nM -
CHEMBL5409723 IC50 > 20000.0 nM -
CHEMBL5431318 IC50 > 20000.0 nM -
CHEMBL5401386 IC50 > 20000.0 nM -
CHEMBL5433797 IC50 > 20000.0 nM -
CHEMBL5400338 IC50 > 20000.0 nM -
CHEMBL5400453 IC50 > 20000.0 nM -